Christine Klein Selected Research

Movement Disorders (Movement Disorder)

1/2021	Genotype-Phenotype Relations for the Atypical Parkinsonism Genes: MDSGene Systematic Review.
1/2021	Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.
10/2020	Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism.
1/2019	A hexanucleotide repeat modifies expressivity of X-linked dystonia parkinsonism.
1/2019	Will genotype drive treatment options?
1/2018	Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism.
4/2016	Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force.
12/2015	The evolving spectrum of PRRT2-associated paroxysmal diseases.
2/2015	CLPB mutations cause 3-methylglutaconic aciduria, progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder.
10/2012	Phenotypes and genetic architecture of focal primary torsion dystonia.

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Christine Klein Research Topics

Disease

81	Parkinson Disease (Parkinson's Disease) 10/2022 - 09/2005
31	Dystonia (Limb Dystonia) 11/2022 - 08/2002
28	Parkinsonian Disorders (Parkinsonism) 01/2022 - 04/2002
18	Movement Disorders (Movement Disorder) 01/2021 - 11/2002
11	Myoclonic dystonia 01/2022 - 11/2002
10	X-Linked Torsion Dystonia 3 11/2022 - 09/2014
10	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 07/2012
8	Dystonia musculorum deformans type 1 09/2014 - 11/2002
7	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2022 - 09/2010
7	Dopa-responsive Dystonia 01/2022 - 01/2014
6	Inflammation (Inflammations) 10/2022 - 01/2018
6	Dyskinesias (Dyskinesia) 01/2017 - 11/2006
4	Atrophy 11/2022 - 11/2010
4	Genetic Predisposition to Disease (Genetic Predisposition) 01/2021 - 12/2004
3	Cognitive Dysfunction 06/2021 - 11/2010
3	Chorea (Rheumatic Chorea) 01/2018 - 01/2016
3	Task-Specific Focal Dystonia 04/2016 - 06/2014
3	Gaucher Disease (Gaucher's Disease) 06/2013 - 07/2010
3	Dystonic Disorders (Writer's Cramp) 02/2011 - 05/2010
2	Myoclonus (Nocturnal Myoclonus) 01/2022 - 08/2010
2	Infections 01/2022 - 06/2012
2	COVID-19 01/2022 - 06/2021
2	Bites and Stings (Sting) 10/2020 - 01/2018
2	Neoplasms (Cancer) 01/2020 - 11/2003
2	Neuroblastoma 01/2019 - 01/2017
2	Disease Progression 04/2017 - 01/2017
2	Tremor (Tremors) 01/2017 - 08/2010
2	Sialorrhea 01/2010 - 04/2004
1	Necrosis 10/2022
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Venous Thrombosis (Deep-Vein Thrombosis) 10/2021
1	Thrombocytopenia (Thrombopenia) 10/2021

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2002
17	Phosphotransferases (Kinase)IBA 01/2021 - 09/2006
12	Leucine (L-Leucine)FDA Link 01/2021 - 09/2006
10	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 05/2009
9	alpha-SynucleinIBA 01/2021 - 09/2005
9	Sarcoglycans (beta Sarcoglycan)IBA 10/2017 - 11/2002
8	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 09/2005
8	SynucleinsIBA 01/2021 - 04/2012
7	Retroelements (Retrotransposon)IBA 11/2022 - 01/2018
7	Biomarkers (Surrogate Marker)IBA 10/2022 - 08/2007
7	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 07/2010
6	IronIBA 01/2022 - 09/2010
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 04/2007
5	Mitochondrial DNA (mtDNA)IBA 01/2022 - 01/2018
5	EnzymesIBA 01/2020 - 04/2002
5	PTEN-induced putative kinaseIBA 01/2017 - 06/2006
4	Pharmaceutical PreparationsIBA 01/2022 - 04/2004
4	Botulinum Toxins (Botulinum Toxin)IBA 10/2013 - 04/2004
4	Adenosine Triphosphatases (ATPase)IBA 09/2012 - 08/2007
4	Antipsychotic Agents (Antipsychotics)IBA 04/2011 - 04/2004
3	CytokinesIBA 10/2022 - 01/2018
3	Interleukin-6 (Interleukin 6)IBA 10/2022 - 01/2018
3	AntibodiesIBA 01/2022 - 11/2003
3	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2022 - 01/2020
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022 - 08/2010
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 10/2010
3	NucleotidesIBA 12/2020 - 09/2014
3	Messenger RNA (mRNA)IBA 01/2017 - 02/2015
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2014 - 11/2007
2	TubulinIBA 11/2022 - 04/2013
2	C-Reactive ProteinIBA 10/2022 - 10/2020
2	Nonsense Codon (Nonsense Mutation)IBA 01/2022 - 02/2016
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
2	sapropterin (tetrahydrobiopterin)FDA Link 01/2022 - 11/2011
2	InterferonsIBA 01/2021 - 10/2020
2	Prokaryotic Initiation Factor-2IBA 01/2021 - 01/2021
2	hydrogen sulfite (bisulfite)IBA 12/2020 - 10/2008
2	UbiquitinIBA 01/2019 - 11/2018
2	LipidsIBA 01/2018 - 01/2017
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 12/2017 - 01/2014
2	Caffeine (No Doz)FDA LinkGeneric 04/2017 - 11/2006
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2017 - 01/2016
2	UbiquinoneIBA 01/2017 - 07/2012
2	Guanosine Triphosphate (GTP)IBA 08/2012 - 12/2011
2	P-type ATPasesIBA 06/2012 - 02/2009
2	rimabotulinumtoxinB FDA Link 01/2010 - 08/2002
2	Clozapine (Clozaril)FDA LinkGeneric 01/2010 - 04/2004
2	Dihydroxyphenylalanine (Dopa)IBA 08/2002 - 07/2002
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 10/2022
1	Coffee FDA Link 08/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/2022
1	Clonazepam (Rivotril)FDA LinkGeneric 01/2022
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2022
1	LipopolysaccharidesIBA 01/2022
1	InterleukinsIBA 01/2022
1	CeramidesIBA 10/2021
1	2019-nCoV Vaccine mRNA-1273IBA 10/2021
1	BNT162 VaccineIBA 10/2021
1	COVID-19 VaccinesIBA 10/2021
1	VaccinesIBA 10/2021

Therapy/Procedure

14	Therapeutics 01/2022 - 07/2010
6	Deep Brain Stimulation 01/2019 - 08/2002
3	Precision Medicine 02/2021 - 01/2020
2	Activities of Daily Living (ADL) 01/2022 - 01/2019
2	Transcranial Magnetic Stimulation 04/2016 - 10/2015
2	Injections 01/2010 - 04/2004
1	Self-Testing 01/2022